Assay Detail
Binding
CHEMBL3595073
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Inhibition of human plasma kallikrein using S2302 as substrate measured for 30 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.96 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3594313 | — | — | 1 | 7.30 |
| CHEMBL3594314 | — | — | 1 | 5.77 |
| CHEMBL3594311 | — | — | 1 | 5.44 |
| CHEMBL3594310 | — | — | 1 | 5.34 |
| CHEMBL3594312 | — | — | 1 | - |
| CHEMBL3594305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3594313 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3594314 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL3594311 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL3594310 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL3594312 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL3594305 | — | Ki | > | 6000.0 | nM | - |