Assay Detail
Binding
CHEMBL3595280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TNKS1 (1030 to 1317) using NAD substrate after 20 mins incubation by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Poly [ADP-ribose] polymerase tankyrase-1 (CHEMBL6164) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.95 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593715 | — | — | 1 | 6.43 |
| CHEMBL3594137 | — | — | 1 | 6.21 |
| CHEMBL3594136 | — | — | 1 | 5.96 |
| CHEMBL3593716 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593715 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3594137 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3594136 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3593716 | — | IC50 | = | 6300.0 | nM | 5.20 |