Assay Detail
Binding
CHEMBL3595284
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ARTD4 (250 to 565) using 500 nM NAD substrate after 2.5 hrs incubation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP4 (CHEMBL6142) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.63 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593716 | — | — | 1 | 4.77 |
| CHEMBL3593715 | — | — | 1 | 4.48 |
| CHEMBL3594136 | — | — | 1 | - |
| CHEMBL3594137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593716 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3593715 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3594136 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3594137 | — | IC50 | > | 100000.0 | nM | - |