Assay Detail
Functional
CHEMBL3595591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 5.78 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373571 | — | — | 1 | 9.85 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.39 |
| CHEMBL3593877 | — | — | 1 | 6.62 |
| CHEMBL3593248 | — | — | 1 | 6.47 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 6.18 |
| CHEMBL3593512 | — | — | 1 | 6.09 |
| CHEMBL3593880 | — | — | 1 | 5.92 |
| CHEMBL3593506 | — | — | 1 | 5.85 |
| CHEMBL3593504 | — | — | 1 | 5.85 |
| CHEMBL3593879 | — | — | 1 | 5.41 |
| CHEMBL3593507 | — | — | 1 | 5.37 |
| CHEMBL3593511 | — | — | 1 | 5.29 |
| CHEMBL3593881 | — | — | 1 | 5.28 |
| CHEMBL3593510 | — | — | 1 | 5.23 |
| CHEMBL3593508 | — | — | 1 | 5.22 |
| CHEMBL3593513 | — | — | 1 | 5.14 |
| CHEMBL3593509 | — | — | 1 | 5.10 |
| CHEMBL3593878 | — | — | 1 | 5.10 |
| CHEMBL3593876 | — | — | 1 | 5.10 |
| CHEMBL3593875 | — | — | 1 | 5.09 |
| CHEMBL3593514 | — | — | 1 | 5.08 |
| CHEMBL3593503 | — | — | 1 | 4.97 |
| CHEMBL3593505 | — | — | 1 | 4.39 |
| CHEMBL3593874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373571 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3593877 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3593248 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL593 | DELAVIRDINE | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3593512 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3593880 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3593506 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3593504 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3593879 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3593507 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3593511 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3593881 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3593510 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3593508 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3593513 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3593509 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3593878 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3593876 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3593875 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3593514 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3593503 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3593505 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL3593874 | — | EC50 | > | 320000.0 | nM | - |