Assay Detail
Functional
CHEMBL3595592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RES056 expressing reverse transcriptase K103N + Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 8.62 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373571 | — | — | 1 | 9.64 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.60 |
| CHEMBL3593881 | — | — | 1 | - |
| CHEMBL3593880 | — | — | 1 | - |
| CHEMBL3593879 | — | — | 1 | - |
| CHEMBL3593878 | — | — | 1 | - |
| CHEMBL3593877 | — | — | 1 | - |
| CHEMBL3593876 | — | — | 1 | - |
| CHEMBL3593875 | — | — | 1 | - |
| CHEMBL3593874 | — | — | 1 | - |
| CHEMBL3593504 | — | — | 1 | - |
| CHEMBL3593248 | — | — | 1 | - |
| CHEMBL3593505 | — | — | 1 | - |
| CHEMBL3593503 | — | — | 1 | - |
| CHEMBL3593507 | — | — | 1 | - |
| CHEMBL3593508 | — | — | 1 | - |
| CHEMBL3593509 | — | — | 1 | - |
| CHEMBL3593510 | — | — | 1 | - |
| CHEMBL3593511 | — | — | 1 | - |
| CHEMBL3593512 | — | — | 1 | - |
| CHEMBL3593513 | — | — | 1 | - |
| CHEMBL3593514 | — | — | 1 | - |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | - |
| CHEMBL3593506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373571 | — | EC50 | = | 0.23 | nM | 9.64 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3593881 | — | EC50 | > | 89000.0 | nM | - |
| CHEMBL3593880 | — | EC50 | > | 272000.0 | nM | - |
| CHEMBL3593879 | — | EC50 | > | 294000.0 | nM | - |
| CHEMBL3593878 | — | EC50 | > | 294000.0 | nM | - |
| CHEMBL3593877 | — | EC50 | >= | 10900.0 | nM | - |
| CHEMBL3593876 | — | EC50 | > | 306000.0 | nM | - |
| CHEMBL3593875 | — | EC50 | > | 306000.0 | nM | - |
| CHEMBL3593874 | — | EC50 | > | 320000.0 | nM | - |
| CHEMBL3593504 | — | EC50 | > | 24000.0 | nM | - |
| CHEMBL3593248 | — | EC50 | > | 287000.0 | nM | - |
| CHEMBL3593505 | — | EC50 | > | 287000.0 | nM | - |
| CHEMBL3593503 | — | EC50 | > | 41000.0 | nM | - |
| CHEMBL3593507 | — | EC50 | > | 301000.0 | nM | - |
| CHEMBL3593508 | — | EC50 | > | 288000.0 | nM | - |
| CHEMBL3593509 | — | EC50 | > | 266000.0 | nM | - |
| CHEMBL3593510 | — | EC50 | > | 309000.0 | nM | - |
| CHEMBL3593511 | — | EC50 | > | 309000.0 | nM | - |
| CHEMBL3593512 | — | EC50 | > | 46000.0 | nM | - |
| CHEMBL3593513 | — | EC50 | > | 69000.0 | nM | - |
| CHEMBL3593514 | — | EC50 | > | 71000.0 | nM | - |
| CHEMBL593 | DELAVIRDINE | EC50 | > | 44000.0 | nM | - |
| CHEMBL3593506 | — | EC50 | > | 287000.0 | nM | - |