Assay Detail
Binding
CHEMBL3595644
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Inhibition of urease isolated from Helicobacter pylori ATCC 43504 assessed as ammonia production incubated for 1.5 hrs prior to testing by indophenol method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori ATCC 43504 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
Synthesis and evaluation of N-analogs of 1,2-diarylethane as Helicobacter pylori urease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.75 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3594250 | — | — | 1 | 6.21 |
| CHEMBL3594254 | — | — | 1 | 5.63 |
| CHEMBL3594251 | — | — | 1 | 5.08 |
| CHEMBL3594256 | — | — | 1 | 4.88 |
| CHEMBL3594257 | — | — | 1 | 4.78 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | 4.74 |
| CHEMBL3594252 | — | — | 1 | 4.71 |
| CHEMBL3594253 | — | — | 1 | 4.58 |
| CHEMBL3594261 | — | — | 1 | 4.35 |
| CHEMBL3594255 | — | — | 1 | 4.30 |
| CHEMBL3594258 | — | — | 1 | 4.24 |
| CHEMBL3594259 | — | — | 1 | 4.19 |
| CHEMBL3594260 | — | — | 1 | 4.07 |
| CHEMBL3594262 | — | — | 1 | - |
| CHEMBL3594263 | — | — | 1 | - |
| CHEMBL3594264 | — | — | 1 | - |
| CHEMBL3594265 | — | — | 1 | - |
| CHEMBL3594266 | — | — | 1 | - |
| CHEMBL3594267 | — | — | 1 | - |
| CHEMBL3594268 | — | — | 1 | - |
| CHEMBL3593637 | — | — | 1 | - |
| CHEMBL3593638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3594250 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3594254 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL3594251 | — | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL3594256 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL3594257 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL3594252 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL3594253 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL3594261 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL3594255 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL3594258 | — | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL3594259 | — | IC50 | = | 64900.0 | nM | 4.19 |
| CHEMBL3594260 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL3594262 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3594263 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3594264 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3594265 | — | IC50 | = | 238700.0 | nM | - |
| CHEMBL3594266 | — | IC50 | = | 236500.0 | nM | - |
| CHEMBL3594267 | — | IC50 | = | 410300.0 | nM | - |
| CHEMBL3594268 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3593637 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3593638 | — | IC50 | = | 319200.0 | nM | - |