Assay Detail
Binding
CHEMBL3595648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE10A (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL4409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase 10A (PDE10A) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.16 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562318 | MARDEPODECT | 2.0 | 1 | 8.59 |
| CHEMBL2419369 | — | — | 1 | 7.92 |
| CHEMBL2419366 | — | — | 1 | 7.62 |
| CHEMBL2419561 | — | — | 1 | 7.51 |
| CHEMBL3593644 | — | — | 1 | 7.19 |
| CHEMBL3593639 | — | — | 1 | 6.77 |
| CHEMBL2419564 | — | — | 1 | 6.60 |
| CHEMBL3593645 | — | — | 1 | 6.48 |
| CHEMBL3593643 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562318 | MARDEPODECT | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2419369 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2419366 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2419561 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3593644 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3593639 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2419564 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3593645 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3593643 | — | IC50 | = | 1800.0 | nM | 5.75 |