Compound Detail
CHEMBL3593645
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Basic Information
| ChEMBL ID | CHEMBL3593645 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JLHLDWMYWBQUEP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names
Molecular Properties
452.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL4409 | IC50 | 6.48 | 6.48 | 330.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 283.33 | mL.min-1.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | IC50 | = | 330.0 | nM | 6.48 | Inhibition of PDE10A (unknown origin) | 26113188 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26113188 | 10.1016/j.bmc.2015.06.019 | Liver microsome | 1 |
| 26113188 | 10.1016/j.bmc.2015.06.019 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 1 |
Data from ChEMBL 36 via Core Engine