Assay Detail
Binding
CHEMBL3595654
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Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate after 5 mins by Ellman's method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.99 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.92 |
| CHEMBL3338391 | — | — | 1 | 7.68 |
| CHEMBL3593658 | — | — | 1 | 6.67 |
| CHEMBL3593652 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3338391 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3593658 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL3593652 | — | IC50 | = | 2140.0 | nM | 5.67 |