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Assay Detail

CHEMBL3595847

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Polycyclic Polyprenylated Xanthones from Symphonia globulifera: Isolation and Biomimetic Electrosynthesis.
Cottet K, Neudörffer A, Kritsanida M, Michel S, Lallemand MC, Largeron M.
J Nat Prod (2015) 78 : 2136 -2140
PubMed 26221771 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.28 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3593388 1 5.52
CHEMBL452483 GUTTIFERONE A 1 5.22
CHEMBL3593387 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3593388 IC50 = 3000.0 nM 5.52
CHEMBL452483 GUTTIFERONE A IC50 = 6000.0 nM 5.22
CHEMBL3593387 IC50 = 8000.0 nM 5.10