Assay Detail
Binding
CHEMBL3595969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human kidney Na(+)/K(+) ATPase alpha-1 assessed as amount of Pi release after 1 hr by colorimetric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium/potassium-transporting ATPase subunit alpha-1 (CHEMBL1807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.84 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.54 |
| CHEMBL3594278 | — | — | 1 | 6.47 |
| CHEMBL3594276 | — | — | 1 | 6.24 |
| CHEMBL3856118 | — | — | 1 | 5.01 |
| CHEMBL3594280 | — | — | 1 | 4.96 |
| CHEMBL3594277 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1751 | DIGOXIN | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3594278 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3594276 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3856118 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3594280 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3594277 | — | IC50 | - | — | - |