Assay Detail
Binding
CHEMBL3596033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.49 | 9.49 |
| pEC50 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511857 | — | — | 1 | 9.49 |
| CHEMBL423181 | — | — | 1 | 8.45 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 7.29 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.77 |
| CHEMBL140406 | — | — | 1 | 5.47 |
| CHEMBL444590 | — | — | 1 | - |
| CHEMBL139505 | — | — | 1 | - |
| CHEMBL344146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511857 | — | EC50 | = | 0.3236 | nM | 9.49 |
| CHEMBL423181 | — | EC50 | = | 3.548 | nM | 8.45 |
| CHEMBL56 | 8-OH-DPAT | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL39 | SEROTONIN | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL140406 | — | EC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL444590 | — | pEC50 | - | — | - | |
| CHEMBL139505 | — | pEC50 | - | — | - | |
| CHEMBL344146 | — | pEC50 | - | — | - |