Assay Detail
Binding
CHEMBL3596064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human TRPA1 expressed in TREx-HEK cells by Fluo-4 AM dye-based Ca2+ imaging assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | TREx-HEK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL6007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Activity Relationship Study on Isothiocyanates: Comparison of TRPA1-Activating Ability between Allyl Isothiocyanate and Specific Flavor Components of Wasabi, Horseradish, and White Mustard.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.17 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55285 | BENZYL ISOTHIOCYANATE | — | 1 | 6.60 |
| CHEMBL3593942 | — | — | 1 | 6.44 |
| CHEMBL151649 | PHENETHYLISOTHIOCYANATE | — | 1 | 6.43 |
| CHEMBL2151143 | ERUCIN | — | 1 | 6.38 |
| CHEMBL3186484 | — | — | 1 | 6.35 |
| CHEMBL3593947 | — | — | 1 | 6.30 |
| CHEMBL2208211 | ISOPROPYL ISOTHIOCYANATE | — | 1 | 6.28 |
| CHEMBL3593943 | — | — | 1 | 6.27 |
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | 1.0 | 1 | 6.24 |
| CHEMBL574688 | — | — | 1 | 6.24 |
| CHEMBL3593948 | — | — | 1 | 6.21 |
| CHEMBL3593576 | — | — | 1 | 6.17 |
| CHEMBL3593941 | — | — | 1 | 6.16 |
| CHEMBL3593944 | — | — | 1 | 5.98 |
| CHEMBL3593945 | — | — | 1 | 5.98 |
| CHEMBL3593946 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55285 | BENZYL ISOTHIOCYANATE | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3593942 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL151649 | PHENETHYLISOTHIOCYANATE | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2151143 | ERUCIN | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3186484 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3593947 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2208211 | ISOPROPYL ISOTHIOCYANATE | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3593943 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL574688 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3593948 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3593576 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3593941 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3593944 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3593945 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3593946 | — | EC50 | = | 20000.0 | nM | 4.70 |