Assay Detail
Functional
CHEMBL3598438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell viability after 48 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.46 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3597747 | — | — | 1 | 5.88 |
| CHEMBL258893 | CHELERYTHRINE CHLORIDE | — | 1 | 5.67 |
| CHEMBL3597750 | — | — | 1 | 5.49 |
| CHEMBL492185 | — | — | 1 | 5.49 |
| CHEMBL3597749 | — | — | 1 | 5.47 |
| CHEMBL8443 | NITIDINE CHLORIDE | — | 1 | 5.36 |
| CHEMBL487807 | — | — | 1 | 5.18 |
| CHEMBL3597752 | — | — | 1 | 5.14 |
| CHEMBL3597758 | — | — | 1 | - |
| CHEMBL3597757 | — | — | 1 | - |
| CHEMBL3597756 | — | — | 1 | - |
| CHEMBL3597748 | — | — | 1 | - |
| CHEMBL521226 | — | — | 1 | - |
| CHEMBL3597755 | — | — | 1 | - |
| CHEMBL3597751 | — | — | 1 | - |
| CHEMBL400359 | DIHYDROCHELERYTHRINE | — | 1 | - |
| CHEMBL1182694 | — | — | 1 | - |
| CHEMBL3597759 | — | — | 1 | - |
| CHEMBL3597753 | — | — | 1 | - |
| CHEMBL3597754 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3597747 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL258893 | CHELERYTHRINE CHLORIDE | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL3597750 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL492185 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL3597749 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL8443 | NITIDINE CHLORIDE | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL487807 | — | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL3597752 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL3597758 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597757 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597756 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597748 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL521226 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597755 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597751 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL400359 | DIHYDROCHELERYTHRINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1182694 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597759 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597753 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597754 | — | IC50 | > | 10000.0 | nM | - |