Assay Detail
Binding
CHEMBL3598916
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Inhibition of human HDAC4
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.47 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 9.52 |
| CHEMBL1851943 | PRACINOSTAT | 3.0 | 1 | 7.80 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 6.42 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 6.26 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 5.98 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.85 |
| CHEMBL314389 | OXAMFLATIN | — | 1 | 5.69 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 5.65 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105763 | QUISINOSTAT | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1851943 | PRACINOSTAT | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL1213492 | GIVINOSTAT | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL314389 | OXAMFLATIN | Ki | = | 2032.6 | nM | 5.69 |
| CHEMBL356066 | DACINOSTAT | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL356769 | TUBACIN | Ki | = | 9124.2 | nM | 5.04 |