Assay Detail
Binding
CHEMBL3598918
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Inhibition of human HDAC7
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.30 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 7.18 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.12 |
| CHEMBL1851943 | PRACINOSTAT | 3.0 | 1 | 6.97 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.71 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 6.62 |
| CHEMBL314389 | OXAMFLATIN | — | 1 | 6.49 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 5.34 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.26 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105763 | QUISINOSTAT | Ki | = | 66.6 | nM | 7.18 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL1851943 | PRACINOSTAT | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL1213492 | GIVINOSTAT | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL314389 | OXAMFLATIN | Ki | = | 324.7 | nM | 6.49 |
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 4550.0 | nM | 5.34 |
| CHEMBL356769 | TUBACIN | Ki | = | 5426.9 | nM | 5.26 |
| CHEMBL356066 | DACINOSTAT | Ki | = | 9500.0 | nM | 5.02 |