Assay Detail
Functional
CHEMBL3602172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.28 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2393394 | — | — | 1 | 8.96 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 8.60 |
| CHEMBL3601865 | — | — | 1 | 8.59 |
| CHEMBL3601864 | — | — | 1 | 8.59 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.05 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.01 |
| CHEMBL3601863 | — | — | 1 | 7.94 |
| CHEMBL3601867 | — | — | 1 | 7.89 |
| CHEMBL3601866 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2393394 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3601865 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3601864 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3601863 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL3601867 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL3601866 | — | IC50 | = | 12.8 | nM | 7.89 |