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Compound Detail

CHEMBL3601863

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C[C@H]1[C@@H](CCCO)O[C@@H]2O[C@@]3(C)CC[C@H]4[C@H](C)CC[C@@H]1[C@@]24OO3

Basic Information

ChEMBL ID CHEMBL3601863
Phase Preclinical
Structure Type MOL
InChI Key BAJSYLWSYBXRPS-VMAIWCPRSA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

326.4
MW (Da)
3.01
ALogP
5
HBA
1
HBD
57.1
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H30O5
MW 326.43
Aromatic Rings 0
Heavy Atoms 23
NP-Likeness 3.50

Activity Summary

IC50 3 meas. best 7.94

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Plasmodium falciparum
CHEMBL364
IC50 7.94 7.94 11.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26260339 10.1016/j.bmc.2015.07.048 Plasmodium falciparum 1
26260339 10.1016/j.bmc.2015.07.048 NON-PROTEIN TARGET 1
26260339 10.1016/j.bmc.2015.07.048 CCRF-CEM 1
28456567 10.1016/j.bmc.2017.04.021 CCRF-CEM 1
28456567 10.1016/j.bmc.2017.04.021 ADR5000 cell line 1

Data from ChEMBL 36 via Core Engine