Assay Detail
Functional
CHEMBL3602175
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Cytotoxicity against human CEM/ADR5000 cells assessed as cell viability after 72 hrs by resazurin assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ADR5000 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.25 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2393394 | — | — | 1 | 7.30 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 6.72 |
| CHEMBL3601866 | — | — | 1 | 6.70 |
| CHEMBL3601865 | — | — | 1 | 6.70 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 6.57 |
| CHEMBL3601867 | — | — | 1 | 6.31 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.79 |
| CHEMBL3601864 | — | — | 1 | 5.55 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2393394 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3601866 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3601865 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3601867 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3601864 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 26900.0 | nM | 4.57 |