Assay Detail
Functional
CHEMBL3602339
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Anti-leishmanial activity against Leishmania amazonensis MPRO/BR/1972/M1841-LV-79 amastigotes infected in BALB/c mouse peritoneal macrophages assessed as reduction in the infection index incubated for 24 hrs by Giemsa staining method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.00 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601622 | — | — | 1 | 5.54 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 5.31 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.20 |
| CHEMBL3601621 | — | — | 1 | 4.70 |
| CHEMBL3601624 | — | — | 1 | 4.66 |
| CHEMBL3601623 | — | — | 1 | 4.59 |
| CHEMBL147067 | — | — | 1 | - |
| CHEMBL388322 | 3-HYDROXY CHALCONE | — | 1 | - |
| CHEMBL7976 | CHALCONE | — | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601622 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL3601621 | — | EC50 | = | 19930.0 | nM | 4.70 |
| CHEMBL3601624 | — | EC50 | = | 21890.0 | nM | 4.66 |
| CHEMBL3601623 | — | EC50 | = | 25810.0 | nM | 4.59 |
| CHEMBL147067 | — | EC50 | - | — | - | |
| CHEMBL388322 | 3-HYDROXY CHALCONE | EC50 | - | — | - | |
| CHEMBL7976 | CHALCONE | EC50 | - | — | - | |
| CHEMBL110 | BENZNIDAZOLE | EC50 | - | — | - |