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Assay Detail

CHEMBL3602341

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Functional
Anti-leishmanial activity against Leishmania infantum MHOM/BR/72 promastigotes assessed as parasite growth inhibition incubated for 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania infantum
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania infantum (CHEMBL612848)
Type ORGANISM
Organism Leishmania infantum

Publication

Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.
Passalacqua TG, Dutra LA, de Almeida L, Velásquez AM, Torres FA, Yamasaki PR, dos Santos MB, Regasini LO, Michels PA, Bolzani Vda S, Graminha MA.
Bioorg Med Chem Lett (2015) 25 : 3342 -3345
PubMed 26055530 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 4.99 6.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.04
CHEMBL3601621 1 5.33
CHEMBL3601624 1 5.22
CHEMBL3601623 1 5.11
CHEMBL7976 CHALCONE 1 5.05
CHEMBL3601622 1 4.99
CHEMBL55 PENTAMIDINE 4.0 1 4.17
CHEMBL147067 1 4.04
CHEMBL388322 3-HYDROXY CHALCONE 1 -
CHEMBL110 BENZNIDAZOLE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B EC50 = 920.0 nM 6.04
CHEMBL3601621 EC50 = 4690.0 nM 5.33
CHEMBL3601624 EC50 = 5980.0 nM 5.22
CHEMBL3601623 EC50 = 7810.0 nM 5.11
CHEMBL7976 CHALCONE EC50 = 8890.0 nM 5.05
CHEMBL3601622 EC50 = 10210.0 nM 4.99
CHEMBL55 PENTAMIDINE EC50 = 67710.0 nM 4.17
CHEMBL147067 EC50 = 91740.0 nM 4.04
CHEMBL388322 3-HYDROXY CHALCONE EC50 = 184820.0 nM -
CHEMBL110 BENZNIDAZOLE EC50 - -