Assay Detail
Functional
CHEMBL3602365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against T-cell line-tropic HIV1 NL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity after 5 days by MTT assay in presence of 10 uM of chloroquine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-HIV screening for cell-penetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.45 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600990 | — | — | 1 | 6.70 |
| CHEMBL1946511 | — | — | 1 | 6.19 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600990 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1946511 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL129 | ZIDOVUDINE | EC50 | - | — | - | |
| CHEMBL18442 | PLERIXAFOR | EC50 | - | — | - |