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Assay Detail

CHEMBL3602383

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against CHO cells by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Cricetulus griseus
Cell Type CHO
Confidence 1 — Organism
Curated By Autocuration

Target

CHO (CHEMBL613853)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Syntheses and in Vitro Antiplasmodial Activity of Aminoalkylated Chalcones and Analogues.
Wilhelm A, Kendrekar P, Noreljaleel AE, Abay ET, Bonnet SL, Wiesner L, de Kock C, Swart KJ, van der Westhuizen JH.
J Nat Prod (2015) 78 : 1848 -1858
PubMed 26235033 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.08 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50588 EMETINE 4.0 1 7.52
CHEMBL3601842 1 5.30
CHEMBL3600399 1 5.18
CHEMBL3601702 1 5.14
CHEMBL3601701 1 5.08
CHEMBL3601840 1 4.64
CHEMBL3601843 1 4.60
CHEMBL3601838 1 4.16
CHEMBL3601703 1 4.11
CHEMBL3601692 1 -
CHEMBL3601835 1 -
CHEMBL3601839 1 -
CHEMBL3601854 1 -
CHEMBL3601855 1 -
CHEMBL3601856 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50588 EMETINE IC50 = 30.0 nM 7.52
CHEMBL3601842 IC50 = 4950.0 nM 5.30
CHEMBL3600399 IC50 = 6590.0 nM 5.18
CHEMBL3601702 IC50 = 7270.0 nM 5.14
CHEMBL3601701 IC50 = 8220.0 nM 5.08
CHEMBL3601840 IC50 = 23060.0 nM 4.64
CHEMBL3601843 IC50 = 25200.0 nM 4.60
CHEMBL3601838 IC50 = 69840.0 nM 4.16
CHEMBL3601703 IC50 = 77250.0 nM 4.11
CHEMBL3601692 IC50 = 196740.0 nM -
CHEMBL3601835 IC50 = 168320.0 nM -
CHEMBL3601839 IC50 = 200080.0 nM -
CHEMBL3601854 IC50 = 211350.0 nM -
CHEMBL3601855 IC50 = 163280.0 nM -
CHEMBL3601856 IC50 = 161650.0 nM -