Assay Detail
Binding
CHEMBL3602569
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Inhibition of human erythrocytes CA1 using 4-nitrophenylacetate as substrate by esterase assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.59 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14060 | PHENOL | 4.0 | 1 | 4.99 |
| CHEMBL3601880 | — | — | 1 | 4.96 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 4.44 |
| CHEMBL1233360 | — | — | 1 | 4.30 |
| CHEMBL1650614 | — | — | 1 | 4.24 |
| CHEMBL3601878 | — | — | 1 | - |
| CHEMBL3601879 | — | — | 1 | - |
| CHEMBL11470 | — | — | 1 | - |
| CHEMBL24147 | RESORCINOL | -1.0 | 1 | - |
| CHEMBL280998 | CATECHOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14060 | PHENOL | Ki | = | 10200.0 | nM | 4.99 |
| CHEMBL3601880 | — | Ki | = | 10830.0 | nM | 4.96 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 36200.0 | nM | 4.44 |
| CHEMBL1233360 | — | Ki | = | 49510.0 | nM | 4.30 |
| CHEMBL1650614 | — | Ki | = | 57760.0 | nM | 4.24 |
| CHEMBL3601878 | — | Ki | = | 428000.0 | nM | - |
| CHEMBL3601879 | — | Ki | = | 464000.0 | nM | - |
| CHEMBL11470 | — | Ki | = | 316200.0 | nM | - |
| CHEMBL24147 | RESORCINOL | Ki | = | 795000.0 | nM | - |
| CHEMBL280998 | CATECHOL | Ki | = | 4003000.0 | nM | - |