Assay Detail
Functional
CHEMBL3602696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 pseudovirus infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
The N-Terminal T-T Motif of a Third-Generation HIV-1 Fusion Inhibitor Is Not Required for Binding Affinity and Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.20 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411406 | — | — | 1 | 9.34 |
| CHEMBL3600949 | — | — | 1 | 8.97 |
| CHEMBL428607 | — | — | 1 | 8.94 |
| CHEMBL3600951 | — | — | 1 | 8.89 |
| CHEMBL529902 | — | — | 1 | 8.85 |
| CHEMBL3600950 | — | — | 1 | 8.71 |
| CHEMBL3600952 | — | — | 1 | 8.37 |
| CHEMBL3600954 | — | — | 1 | 7.72 |
| CHEMBL3600953 | — | — | 1 | 7.33 |
| CHEMBL3600956 | — | — | 1 | 7.06 |
| CHEMBL3600955 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411406 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL3600949 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL428607 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL3600951 | — | IC50 | = | 1.29 | nM | 8.89 |
| CHEMBL529902 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL3600950 | — | IC50 | = | 1.93 | nM | 8.71 |
| CHEMBL3600952 | — | IC50 | = | 4.26 | nM | 8.37 |
| CHEMBL3600954 | — | IC50 | = | 18.88 | nM | 7.72 |
| CHEMBL3600953 | — | IC50 | = | 46.82 | nM | 7.33 |
| CHEMBL3600956 | — | IC50 | = | 86.65 | nM | 7.06 |
| CHEMBL3600955 | — | IC50 | = | 954.87 | nM | 6.02 |