Assay Detail
Functional
CHEMBL3602697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 NL4-3 infected in human TZM-bl cells assessed as inhibition of viral replication after 2 days by luciferase reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
The N-Terminal T-T Motif of a Third-Generation HIV-1 Fusion Inhibitor Is Not Required for Binding Affinity and Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.83 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411406 | — | — | 1 | 9.60 |
| CHEMBL3600949 | — | — | 1 | 9.32 |
| CHEMBL428607 | — | — | 1 | 9.28 |
| CHEMBL3600950 | — | — | 1 | 9.27 |
| CHEMBL529902 | — | — | 1 | 9.12 |
| CHEMBL3600951 | — | — | 1 | 9.05 |
| CHEMBL3600952 | — | — | 1 | 8.50 |
| CHEMBL3600954 | — | — | 1 | 7.76 |
| CHEMBL3600953 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411406 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL3600949 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL428607 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL3600950 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL529902 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL3600951 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3600952 | — | IC50 | = | 3.13 | nM | 8.50 |
| CHEMBL3600954 | — | IC50 | = | 17.37 | nM | 7.76 |
| CHEMBL3600953 | — | IC50 | = | 26.09 | nM | 7.58 |