Assay Detail
Functional
CHEMBL3602702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 NL4-3 infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
The N-Terminal T-T Motif of a Third-Generation HIV-1 Fusion Inhibitor Is Not Required for Binding Affinity and Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.32 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600949 | — | — | 1 | 8.96 |
| CHEMBL428607 | — | — | 1 | 8.96 |
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600949 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL428607 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL525076 | ENFUVIRTIDE | IC50 | = | 90.2 | nM | 7.04 |