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Assay Detail

CHEMBL3602820

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by Weatherburn assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canavalia ensiformis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Urease (CHEMBL4161)
Type SINGLE PROTEIN
Organism Canavalia ensiformis

Publication

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies.
Taha M, Ismail NH, Khan A, Shah SA, Anwar A, Halim SA, Fatmi MQ, Imran S, Rahim F, Khan KM.
Bioorg Med Chem Lett (2015) 25 : 3285 -3289
PubMed 26077497 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.35 4.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3600575 1 4.89
CHEMBL3600581 1 4.72
CHEMBL260876 THIOUREA 1 4.68
CHEMBL3600576 1 4.45
CHEMBL734 ACETOHYDROXAMIC ACID 4.0 1 4.38
CHEMBL3600577 1 4.37
CHEMBL3600652 1 4.31
CHEMBL3600578 1 4.27
CHEMBL3600580 1 4.15
CHEMBL3600646 1 4.14
CHEMBL3600648 1 4.09
CHEMBL3600642 1 4.07
CHEMBL3600649 1 4.03
CHEMBL3600643 1 -
CHEMBL3600650 1 -
CHEMBL3600583 1 -
CHEMBL3600582 1 -
CHEMBL3600651 1 -
CHEMBL3600644 1 -
CHEMBL3600579 1 -
CHEMBL3600645 1 -
CHEMBL3600647 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3600575 IC50 = 13000.0 nM 4.89
CHEMBL3600581 IC50 = 19200.0 nM 4.72
CHEMBL260876 THIOUREA IC50 = 21000.0 nM 4.68
CHEMBL3600576 IC50 = 35400.0 nM 4.45
CHEMBL734 ACETOHYDROXAMIC ACID IC50 = 42000.0 nM 4.38
CHEMBL3600577 IC50 = 42900.0 nM 4.37
CHEMBL3600652 IC50 = 49100.0 nM 4.31
CHEMBL3600578 IC50 = 53200.0 nM 4.27
CHEMBL3600580 IC50 = 70800.0 nM 4.15
CHEMBL3600646 IC50 = 71800.0 nM 4.14
CHEMBL3600648 IC50 = 82000.0 nM 4.09
CHEMBL3600642 IC50 = 84800.0 nM 4.07
CHEMBL3600649 IC50 = 92400.0 nM 4.03
CHEMBL3600643 IC50 = 119800.0 nM -
CHEMBL3600650 IC50 = 148500.0 nM -
CHEMBL3600583 IC50 = 102300.0 nM -
CHEMBL3600582 IC50 = 109400.0 nM -
CHEMBL3600651 IC50 - -
CHEMBL3600644 IC50 = 143600.0 nM -
CHEMBL3600579 IC50 = 125500.0 nM -
CHEMBL3600645 IC50 = 110500.0 nM -
CHEMBL3600647 IC50 = 145100.0 nM -