Assay Detail
Binding
CHEMBL3602896
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Antagonist activity at cIAP1-BIR3 domain (unknown origin) assessed as inhibition of interaction with SMAC by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.43 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600717 | — | — | 1 | 8.00 |
| CHEMBL3600735 | — | — | 1 | 6.50 |
| CHEMBL3600734 | — | — | 1 | 6.19 |
| CHEMBL3600733 | — | — | 1 | 5.43 |
| CHEMBL3600732 | — | — | 1 | 4.70 |
| CHEMBL181785 | — | — | 1 | 4.62 |
| CHEMBL3600720 | — | — | 1 | 4.57 |
| CHEMBL3600721 | — | — | 1 | 3.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600717 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3600735 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3600734 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3600733 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3600732 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL181785 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3600720 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3600721 | — | IC50 | = | 410000.0 | nM | 3.39 |