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Assay Detail

CHEMBL3603056

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells assessed as inhibition of cell growth after 6 days by Spectramax fluorescence plate reader analysis
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Sola I, Castellà S, Viayna E, Galdeano C, Taylor MC, Gbedema SY, Pérez B, Clos MV, Jones DC, Fairlamb AH, Wright CW, Kelly JM, Muñoz-Torrero D.
Bioorg Med Chem (2015) 23 : 5156 -5167
PubMed 25678015 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 5.66 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3600468 1 6.24
CHEMBL2021640 1 6.14
CHEMBL252424 1 6.01
CHEMBL3600551 1 5.98
CHEMBL255056 1 5.96
CHEMBL401340 1 5.96
CHEMBL3600555 1 5.96
CHEMBL410770 1 5.93
CHEMBL2021630 1 5.78
CHEMBL3600464 1 5.69
CHEMBL3600467 1 5.67
CHEMBL1187774 1 5.62
CHEMBL2021659 1 5.58
CHEMBL3600556 1 5.56
CHEMBL3600465 1 5.45
CHEMBL3600552 1 5.25
CHEMBL3600466 1 5.20
CHEMBL3600463 1 5.17
CHEMBL2021669 1 4.40
CHEMBL1187082 1 -
CHEMBL1186370 1 -
CHEMBL1186058 1 -
CHEMBL1187001 1 -
CHEMBL3600549 1 -
CHEMBL400544 1 -
CHEMBL3600550 1 -
CHEMBL401273 1 -
CHEMBL401339 1 -
CHEMBL3600553 1 -
CHEMBL3600554 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3600468 IC50 = 570.0 nM 6.24
CHEMBL2021640 IC50 = 730.0 nM 6.14
CHEMBL252424 IC50 = 970.0 nM 6.01
CHEMBL3600551 IC50 = 1040.0 nM 5.98
CHEMBL255056 IC50 = 1110.0 nM 5.96
CHEMBL401340 IC50 = 1100.0 nM 5.96
CHEMBL3600555 IC50 = 1110.0 nM 5.96
CHEMBL410770 IC50 = 1170.0 nM 5.93
CHEMBL2021630 IC50 = 1670.0 nM 5.78
CHEMBL3600464 IC50 = 2060.0 nM 5.69
CHEMBL3600467 IC50 = 2150.0 nM 5.67
CHEMBL1187774 IC50 = 2420.0 nM 5.62
CHEMBL2021659 IC50 = 2630.0 nM 5.58
CHEMBL3600556 IC50 = 2740.0 nM 5.56
CHEMBL3600465 IC50 = 3550.0 nM 5.45
CHEMBL3600552 IC50 = 5580.0 nM 5.25
CHEMBL3600466 IC50 = 6290.0 nM 5.20
CHEMBL3600463 IC50 = 6760.0 nM 5.17
CHEMBL2021669 IC50 = 40000.0 nM 4.40
CHEMBL1187082 IC50 < 3000.0 nM -
CHEMBL1186370 IC50 < 1000.0 nM -
CHEMBL1186058 IC50 < 3000.0 nM -
CHEMBL1187001 IC50 < 3000.0 nM -
CHEMBL3600549 IC50 < 3000.0 nM -
CHEMBL400544 IC50 < 1000.0 nM -
CHEMBL3600550 IC50 < 3000.0 nM -
CHEMBL401273 IC50 < 3000.0 nM -
CHEMBL401339 IC50 < 1000.0 nM -
CHEMBL3600553 IC50 < 1000.0 nM -
CHEMBL3600554 IC50 < 1000.0 nM -
CHEMBL2021632 IC50 < 1000.0 nM -
CHEMBL252753 IC50 < 1000.0 nM -