Assay Detail
Binding
CHEMBL3603059
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Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins prior to substrate addition by Ellman's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.44 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600555 | — | — | 1 | 8.83 |
| CHEMBL3600551 | — | — | 1 | 8.72 |
| CHEMBL3600552 | — | — | 1 | 8.46 |
| CHEMBL3600556 | — | — | 1 | 8.44 |
| CHEMBL3600553 | — | — | 1 | 8.19 |
| CHEMBL3600554 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600555 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL3600551 | — | IC50 | = | 1.92 | nM | 8.72 |
| CHEMBL3600552 | — | IC50 | = | 3.46 | nM | 8.46 |
| CHEMBL3600556 | — | IC50 | = | 3.66 | nM | 8.44 |
| CHEMBL3600553 | — | IC50 | = | 6.46 | nM | 8.19 |
| CHEMBL3600554 | — | IC50 | = | 10.1 | nM | 8.00 |