Assay Detail
Binding
CHEMBL3603108
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Inhibition of jack bean Urease assessed as ammonia production after 15 mins by indophenol method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of new barbituric- and thiobarbituric acid derivatives as potent urease inhibitors: Structure activity relationship and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.57 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601761 | — | — | 1 | 5.07 |
| CHEMBL3601759 | — | — | 1 | 5.05 |
| CHEMBL3601757 | — | — | 1 | 4.89 |
| CHEMBL3601773 | — | — | 1 | 4.82 |
| CHEMBL3601762 | — | — | 1 | 4.72 |
| CHEMBL3601772 | — | — | 1 | 4.71 |
| CHEMBL260876 | THIOUREA | — | 1 | 4.68 |
| CHEMBL3601758 | — | — | 1 | 4.66 |
| CHEMBL3601767 | — | — | 1 | 4.61 |
| CHEMBL3601756 | — | — | 1 | 4.59 |
| CHEMBL3601764 | — | — | 1 | 4.57 |
| CHEMBL3601769 | — | — | 1 | 4.54 |
| CHEMBL3601760 | — | — | 1 | 4.49 |
| CHEMBL3601763 | — | — | 1 | 4.40 |
| CHEMBL3601771 | — | — | 1 | 4.38 |
| CHEMBL3601765 | — | — | 1 | 4.28 |
| CHEMBL3601766 | — | — | 1 | 4.18 |
| CHEMBL3601770 | — | — | 1 | 4.05 |
| CHEMBL3601372 | — | — | 1 | 4.05 |
| CHEMBL3601768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601761 | — | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL3601759 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL3601757 | — | IC50 | = | 12960.0 | nM | 4.89 |
| CHEMBL3601773 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3601762 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL3601772 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL260876 | THIOUREA | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3601758 | — | IC50 | = | 21830.0 | nM | 4.66 |
| CHEMBL3601767 | — | IC50 | = | 24560.0 | nM | 4.61 |
| CHEMBL3601756 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL3601764 | — | IC50 | = | 26660.0 | nM | 4.57 |
| CHEMBL3601769 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL3601760 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL3601763 | — | IC50 | = | 39760.0 | nM | 4.40 |
| CHEMBL3601771 | — | IC50 | = | 41330.0 | nM | 4.38 |
| CHEMBL3601765 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL3601766 | — | IC50 | = | 65300.0 | nM | 4.18 |
| CHEMBL3601770 | — | IC50 | = | 89160.0 | nM | 4.05 |
| CHEMBL3601372 | — | IC50 | = | 88300.0 | nM | 4.05 |
| CHEMBL3601768 | — | IC50 | = | 136400.0 | nM | - |