Assay Detail
Binding
CHEMBL3603195
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human microsomal CYP1A1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerating solution
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.64 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601435 | — | — | 1 | 7.40 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.35 |
| CHEMBL2347912 | — | — | 1 | 6.96 |
| CHEMBL2347756 | — | — | 1 | 6.57 |
| CHEMBL3601433 | — | — | 1 | 6.37 |
| CHEMBL3601434 | — | — | 1 | 6.33 |
| CHEMBL3601436 | — | — | 1 | 5.91 |
| CHEMBL3601508 | — | — | 1 | 4.94 |
| CHEMBL3601441 | — | — | 1 | 4.92 |
| CHEMBL3601438 | — | — | 1 | 4.74 |
| CHEMBL3601437 | — | — | 1 | 4.60 |
| CHEMBL50703 | — | — | 1 | 4.42 |
| CHEMBL3601440 | — | — | 1 | 4.22 |
| CHEMBL3601509 | — | — | 1 | 4.22 |
| CHEMBL3601439 | — | — | 1 | - |
| CHEMBL405845 | FURAFYLLINE | 2.0 | 1 | - |
| CHEMBL3601510 | — | — | 1 | - |
| CHEMBL3601511 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601435 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL2347912 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2347756 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL3601433 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL3601434 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL3601436 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL3601508 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL3601441 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3601438 | — | Ki | = | 18400.0 | nM | 4.74 |
| CHEMBL3601437 | — | Ki | = | 25200.0 | nM | 4.60 |
| CHEMBL50703 | — | Ki | = | 37900.0 | nM | 4.42 |
| CHEMBL3601440 | — | Ki | = | 60600.0 | nM | 4.22 |
| CHEMBL3601509 | — | Ki | = | 60700.0 | nM | 4.22 |
| CHEMBL3601439 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL405845 | FURAFYLLINE | Ki | > | 200000.0 | nM | - |
| CHEMBL3601510 | — | Ki | = | 101000.0 | nM | - |
| CHEMBL3601511 | — | Ki | > | 200000.0 | nM | - |