Assay Detail
Binding
CHEMBL3603196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human microsomal CYP1A2-dependent methoxyresorufin-O-demethylase activity by spectrofluorimetric analysis in presence of NADPH regenerating solution
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.26 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347912 | — | — | 1 | 7.85 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.70 |
| CHEMBL3601433 | — | — | 1 | 7.52 |
| CHEMBL3601434 | — | — | 1 | 7.36 |
| CHEMBL2347756 | — | — | 1 | 7.24 |
| CHEMBL3601435 | — | — | 1 | 7.12 |
| CHEMBL3601436 | — | — | 1 | 7.05 |
| CHEMBL3601440 | — | — | 1 | 6.41 |
| CHEMBL50703 | — | — | 1 | 5.94 |
| CHEMBL3601437 | — | — | 1 | 5.89 |
| CHEMBL3601509 | — | — | 1 | 5.87 |
| CHEMBL3601439 | — | — | 1 | 5.82 |
| CHEMBL3601438 | — | — | 1 | 5.76 |
| CHEMBL3601511 | — | — | 1 | 5.45 |
| CHEMBL3601508 | — | — | 1 | 5.43 |
| CHEMBL3601441 | — | — | 1 | 5.30 |
| CHEMBL3601510 | — | — | 1 | 4.85 |
| CHEMBL405845 | FURAFYLLINE | 2.0 | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347912 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3601433 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3601434 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL2347756 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL3601435 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL3601436 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3601440 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL50703 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL3601437 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL3601509 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL3601439 | — | Ki | = | 1510.0 | nM | 5.82 |
| CHEMBL3601438 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL3601511 | — | Ki | = | 3550.0 | nM | 5.45 |
| CHEMBL3601508 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL3601441 | — | Ki | = | 5020.0 | nM | 5.30 |
| CHEMBL3601510 | — | Ki | = | 14200.0 | nM | 4.85 |
| CHEMBL405845 | FURAFYLLINE | Ki | = | 68000.0 | nM | 4.17 |