Assay Detail
Binding
CHEMBL3603197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human microsomal CYP1B1-dependent ethoxyresorufin-O-deethylase activity by spectrofluorimetric analysis in presence of NADPH regenerating solution
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.78 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347912 | — | — | 1 | 8.25 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.80 |
| CHEMBL2347756 | — | — | 1 | 7.28 |
| CHEMBL3601434 | — | — | 1 | 7.00 |
| CHEMBL3601435 | — | — | 1 | 6.92 |
| CHEMBL3601433 | — | — | 1 | 6.75 |
| CHEMBL3601436 | — | — | 1 | 6.32 |
| CHEMBL3601441 | — | — | 1 | 5.33 |
| CHEMBL3601437 | — | — | 1 | 5.30 |
| CHEMBL50703 | — | — | 1 | 5.13 |
| CHEMBL3601439 | — | — | 1 | 4.92 |
| CHEMBL3601440 | — | — | 1 | 4.69 |
| CHEMBL3601438 | — | — | 1 | 4.67 |
| CHEMBL3601508 | — | — | 1 | 4.65 |
| CHEMBL3601511 | — | — | 1 | 4.52 |
| CHEMBL3601509 | — | — | 1 | 4.33 |
| CHEMBL3601510 | — | — | 1 | 4.33 |
| CHEMBL405845 | FURAFYLLINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347912 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2347756 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL3601434 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3601435 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3601433 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3601436 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL3601441 | — | Ki | = | 4620.0 | nM | 5.33 |
| CHEMBL3601437 | — | Ki | = | 5040.0 | nM | 5.30 |
| CHEMBL50703 | — | Ki | = | 7460.0 | nM | 5.13 |
| CHEMBL3601439 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3601440 | — | Ki | = | 20400.0 | nM | 4.69 |
| CHEMBL3601438 | — | Ki | = | 21200.0 | nM | 4.67 |
| CHEMBL3601508 | — | Ki | = | 22600.0 | nM | 4.65 |
| CHEMBL3601511 | — | Ki | = | 30100.0 | nM | 4.52 |
| CHEMBL3601509 | — | Ki | = | 46800.0 | nM | 4.33 |
| CHEMBL3601510 | — | Ki | = | 46600.0 | nM | 4.33 |
| CHEMBL405845 | FURAFYLLINE | Ki | > | 200000.0 | nM | - |