Assay Detail
Binding
CHEMBL3603206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Time-dependent inhibition of human microsomal CYP1A2-dependent methoxyresorufin-O-demethylase activity by spectrofluorimetric analysis in presence of NADPH regenerating solution
14
Total Activities
12
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| TDI | 10 | - | - |
| Ki | 2 | 6.64 | 6.92 |
| Kinact | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601434 | — | — | 2 | 6.92 |
| CHEMBL3601433 | — | — | 2 | 6.36 |
| CHEMBL3601437 | — | — | 1 | - |
| CHEMBL3601438 | — | — | 1 | - |
| CHEMBL3601439 | — | — | 1 | - |
| CHEMBL3601440 | — | — | 1 | - |
| CHEMBL3601441 | — | — | 1 | - |
| CHEMBL3601508 | — | — | 1 | - |
| CHEMBL50703 | — | — | 1 | - |
| CHEMBL3601509 | — | — | 1 | - |
| CHEMBL3601510 | — | — | 1 | - |
| CHEMBL3601511 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601434 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3601433 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL3601437 | — | TDI | - | — | - | |
| CHEMBL3601438 | — | TDI | - | — | - | |
| CHEMBL3601439 | — | TDI | - | — | - | |
| CHEMBL3601440 | — | TDI | - | — | - | |
| CHEMBL3601441 | — | TDI | - | — | - | |
| CHEMBL3601508 | — | TDI | - | — | - | |
| CHEMBL50703 | — | TDI | - | — | - | |
| CHEMBL3601509 | — | TDI | - | — | - | |
| CHEMBL3601510 | — | TDI | - | — | - | |
| CHEMBL3601511 | — | TDI | - | — | - | |
| CHEMBL3601433 | — | Kinact | = | 0.42 | /min | - |
| CHEMBL3601434 | — | Kinact | = | 0.26 | /min | - |