Assay Detail
Functional
CHEMBL3603293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
94
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 94 | 4.97 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600388 | — | — | 1 | 7.22 |
| CHEMBL3600615 | — | — | 1 | 6.52 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.40 |
| CHEMBL3601678 | — | — | 1 | 6.22 |
| CHEMBL3600613 | — | — | 1 | 6.22 |
| CHEMBL3600612 | — | — | 1 | 6.10 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.00 |
| CHEMBL3601668 | — | — | 1 | 5.85 |
| CHEMBL3601816 | — | — | 1 | 5.62 |
| CHEMBL3600618 | — | — | 1 | 5.57 |
| CHEMBL473368 | — | — | 1 | 5.52 |
| CHEMBL3601679 | — | — | 1 | 5.43 |
| CHEMBL3600624 | — | — | 1 | 5.41 |
| CHEMBL3600621 | — | — | 1 | 5.35 |
| CHEMBL3601809 | — | — | 1 | 5.34 |
| CHEMBL3600619 | — | — | 1 | 5.32 |
| CHEMBL3600617 | — | — | 1 | 5.29 |
| CHEMBL3601807 | — | — | 1 | 5.25 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.20 |
| CHEMBL3600609 | — | — | 1 | 5.15 |
| CHEMBL3601817 | — | — | 1 | 5.15 |
| CHEMBL3601822 | — | — | 1 | 5.04 |
| CHEMBL3601814 | — | — | 1 | 5.00 |
| CHEMBL3600611 | — | — | 1 | 4.98 |
| CHEMBL3600607 | — | — | 1 | 4.94 |
| CHEMBL3601824 | — | — | 1 | 4.93 |
| CHEMBL3601660 | — | — | 1 | 4.93 |
| CHEMBL3601803 | — | — | 1 | 4.85 |
| CHEMBL3601670 | — | — | 1 | 4.77 |
| CHEMBL3601825 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600388 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3600615 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3601678 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3600613 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3600612 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3601668 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3601816 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3600618 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL473368 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3601679 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3600624 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3600621 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3601809 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3600619 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3600617 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3601807 | — | IC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3600609 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3601817 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3601822 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3601814 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3600611 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3600607 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL3601824 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3601660 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3601803 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3601670 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL3601825 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL486598 | EVODIAMINE | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL3601673 | — | IC50 | = | 21870.0 | nM | 4.66 |
| CHEMBL3601811 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL3601666 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL3600606 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL3601821 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3601525 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL3601671 | — | IC50 | = | 34170.0 | nM | 4.47 |
| CHEMBL3601820 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL3601815 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL3601523 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL3600623 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL3601659 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3600605 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL3600625 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL3601677 | — | IC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL3601524 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL3601674 | — | IC50 | = | 52340.0 | nM | 4.28 |
| CHEMBL3600620 | — | IC50 | = | 60300.0 | nM | 4.22 |
| CHEMBL3600608 | — | IC50 | = | 66200.0 | nM | 4.18 |