Assay Detail
Binding
CHEMBL3603320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 (unknown origin) by Z'-Lyte assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Selective Covalent Janus Kinase 3 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.25 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601120 | — | — | 1 | 6.85 |
| CHEMBL3601115 | — | — | 1 | 6.39 |
| CHEMBL3601862 | — | — | 1 | 5.51 |
| CHEMBL3601223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601120 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3601115 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL3601862 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL3601223 | — | IC50 | > | 10000.0 | nM | - |