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Assay Detail

CHEMBL3603326

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JAK3 (unknown origin) by Z'-Lyte assay
ChEMBL ↗
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase JAK3 (CHEMBL2148) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of Selective Covalent Janus Kinase 3 Inhibitors.
Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS.
J Med Chem (2015) 58 : 6589 -6606
PubMed 26258521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 72 8.09 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3601110 — — 1 9.30
CHEMBL3601706 — — 1 9.24
CHEMBL3601242 — — 1 9.22
CHEMBL3601121 — — 1 9.22
CHEMBL3601119 — — 1 9.22
CHEMBL3601112 — — 1 9.22
CHEMBL3601713 — — 1 9.15
CHEMBL3601118 — — 1 9.15
CHEMBL3601723 — — 1 9.15
CHEMBL3601108 — — 1 9.15
CHEMBL3601705 — — 1 9.06
CHEMBL3601726 — — 1 9.05
CHEMBL3601233 — — 1 9.05
CHEMBL3601227 — — 1 9.05
CHEMBL3601111 — — 1 8.96
CHEMBL3601226 — — 1 8.92
CHEMBL3601712 — — 1 8.92
CHEMBL3601231 — — 1 8.89
CHEMBL3601708 — — 1 8.89
CHEMBL3601232 — — 1 8.85
CHEMBL3601106 — — 1 8.85
CHEMBL3601710 — — 1 8.80
CHEMBL3601243 — — 1 8.77
CHEMBL3601707 — — 1 8.70
CHEMBL3601228 — — 1 8.70
CHEMBL3601862 — — 1 8.64
CHEMBL3601715 — — 1 8.64
CHEMBL3601244 — — 1 8.54
CHEMBL3601236 — — 1 8.44
CHEMBL3601127 — — 1 8.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3601110 — IC50 = 0.5 nM 9.30
CHEMBL3601706 — IC50 = 0.58 nM 9.24
CHEMBL3601121 — IC50 = 0.6 nM 9.22
CHEMBL3601119 — IC50 = 0.6 nM 9.22
CHEMBL3601112 — IC50 = 0.6 nM 9.22
CHEMBL3601242 — IC50 = 0.6 nM 9.22
CHEMBL3601713 — IC50 = 0.7 nM 9.15
CHEMBL3601118 — IC50 = 0.7 nM 9.15
CHEMBL3601723 — IC50 = 0.7 nM 9.15
CHEMBL3601108 — IC50 = 0.7 nM 9.15
CHEMBL3601705 — IC50 = 0.87 nM 9.06
CHEMBL3601726 — IC50 = 0.9 nM 9.05
CHEMBL3601233 — IC50 = 0.9 nM 9.05
CHEMBL3601227 — IC50 = 0.9 nM 9.05
CHEMBL3601111 — IC50 = 1.1 nM 8.96
CHEMBL3601226 — IC50 = 1.2 nM 8.92
CHEMBL3601712 — IC50 = 1.2 nM 8.92
CHEMBL3601231 — IC50 = 1.3 nM 8.89
CHEMBL3601708 — IC50 = 1.3 nM 8.89
CHEMBL3601232 — IC50 = 1.4 nM 8.85
CHEMBL3601106 — IC50 = 1.4 nM 8.85
CHEMBL3601710 — IC50 = 1.6 nM 8.80
CHEMBL3601243 — IC50 = 1.7 nM 8.77
CHEMBL3601707 — IC50 = 2.0 nM 8.70
CHEMBL3601228 — IC50 = 2.0 nM 8.70
CHEMBL3601862 — IC50 = 2.3 nM 8.64
CHEMBL3601715 — IC50 = 2.3 nM 8.64
CHEMBL3601244 — IC50 = 2.9 nM 8.54
CHEMBL3601236 — IC50 = 3.6 nM 8.44
CHEMBL3601127 — IC50 = 4.4 nM 8.36
CHEMBL3601230 — IC50 = 4.6 nM 8.34
CHEMBL3601223 — IC50 = 4.8 nM 8.32
CHEMBL3601234 — IC50 = 5.2 nM 8.28
CHEMBL3601238 — IC50 = 6.2 nM 8.21
CHEMBL3601709 — IC50 = 6.6 nM 8.18
CHEMBL3601727 — IC50 = 7.0 nM 8.15
CHEMBL3601237 — IC50 = 7.4 nM 8.13
CHEMBL3601123 — IC50 = 7.8 nM 8.11
CHEMBL3601722 — IC50 = 9.9 nM 8.00
CHEMBL3601711 — IC50 = 12.0 nM 7.92
CHEMBL3601725 — IC50 = 17.0 nM 7.77
CHEMBL3601716 — IC50 = 18.0 nM 7.75
CHEMBL3601235 — IC50 = 20.0 nM 7.70
CHEMBL3601229 — IC50 = 20.0 nM 7.70
CHEMBL3601239 — IC50 = 24.0 nM 7.62
CHEMBL3601714 — IC50 = 30.0 nM 7.52
CHEMBL3601719 — IC50 = 31.0 nM 7.51
CHEMBL3601718 — IC50 = 31.0 nM 7.51
CHEMBL3601224 — IC50 = 46.0 nM 7.34
CHEMBL3601125 — IC50 = 64.0 nM 7.19