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Assay Detail

CHEMBL3603327

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against mouse BA/F3 cells expressing TEL-JAK1 after 72 hrs by cell titer glo assay
ChEMBL ↗
65
Total Activities
65
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type BaF3
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Development of Selective Covalent Janus Kinase 3 Inhibitors.
Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS.
J Med Chem (2015) 58 : 6589 -6606
PubMed 26258521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 64 5.44 6.42
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3601228 — — 1 6.42
CHEMBL3601226 — — 1 6.29
CHEMBL3601705 — — 1 6.15
CHEMBL3601227 — — 1 6.09
CHEMBL3601229 — — 1 5.97
CHEMBL3601723 — — 1 5.88
CHEMBL3601106 — — 1 5.77
CHEMBL3601107 — — 1 5.75
CHEMBL3601125 — — 1 5.74
CHEMBL3601231 — — 1 5.73
CHEMBL3601236 — — 1 5.70
CHEMBL3601706 — — 1 5.70
CHEMBL3601242 — — 1 5.69
CHEMBL3601108 — — 1 5.67
CHEMBL3601711 — — 1 5.63
CHEMBL3601238 — — 1 5.63
CHEMBL3601117 — — 1 5.62
CHEMBL3601237 — — 1 5.61
CHEMBL3601715 — — 1 5.61
CHEMBL3600393 — — 1 5.55
CHEMBL3601244 — — 1 5.55
CHEMBL3601712 — — 1 5.54
CHEMBL3601708 — — 1 5.51
CHEMBL3601119 — — 1 5.51
CHEMBL3601223 — — 1 5.50
CHEMBL3601710 — — 1 5.50
CHEMBL3601230 — — 1 5.50
CHEMBL3601116 — — 1 5.50
CHEMBL3601113 — — 1 5.50
CHEMBL3601232 — — 1 5.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3601228 — IC50 = 378.0 nM 6.42
CHEMBL3601226 — IC50 = 513.0 nM 6.29
CHEMBL3601705 — IC50 = 701.0 nM 6.15
CHEMBL3601227 — IC50 = 821.0 nM 6.09
CHEMBL3601229 — IC50 = 1059.0 nM 5.97
CHEMBL3601723 — IC50 = 1315.0 nM 5.88
CHEMBL3601106 — IC50 = 1686.0 nM 5.77
CHEMBL3601107 — IC50 = 1780.0 nM 5.75
CHEMBL3601125 — IC50 = 1823.0 nM 5.74
CHEMBL3601231 — IC50 = 1857.0 nM 5.73
CHEMBL3601236 — IC50 = 2004.0 nM 5.70
CHEMBL3601706 — IC50 = 2008.0 nM 5.70
CHEMBL3601242 — IC50 = 2043.0 nM 5.69
CHEMBL3601108 — IC50 = 2143.0 nM 5.67
CHEMBL3601238 — IC50 = 2346.0 nM 5.63
CHEMBL3601711 — IC50 = 2324.0 nM 5.63
CHEMBL3601117 — IC50 = 2370.0 nM 5.62
CHEMBL3601237 — IC50 = 2484.0 nM 5.61
CHEMBL3601715 — IC50 = 2480.0 nM 5.61
CHEMBL3600393 — IC50 = 2797.0 nM 5.55
CHEMBL3601244 — IC50 = 2792.0 nM 5.55
CHEMBL3601712 — IC50 = 2854.0 nM 5.54
CHEMBL3601708 — IC50 = 3117.0 nM 5.51
CHEMBL3601119 — IC50 = 3065.0 nM 5.51
CHEMBL3601113 — IC50 = 3129.0 nM 5.50
CHEMBL3601710 — IC50 = 3173.0 nM 5.50
CHEMBL3601116 — IC50 = 3137.0 nM 5.50
CHEMBL3601223 — IC50 = 3124.0 nM 5.50
CHEMBL3601230 — IC50 = 3182.0 nM 5.50
CHEMBL3601232 — IC50 = 3287.0 nM 5.48
CHEMBL3601114 — IC50 = 3462.0 nM 5.46
CHEMBL3601713 — IC50 = 3490.0 nM 5.46
CHEMBL3601110 — IC50 = 3506.0 nM 5.46
CHEMBL3601725 — IC50 = 3457.0 nM 5.46
CHEMBL3601716 — IC50 = 3640.0 nM 5.44
CHEMBL3601127 — IC50 = 3624.0 nM 5.44
CHEMBL3601123 — IC50 = 3825.0 nM 5.42
CHEMBL3601120 — IC50 = 3758.0 nM 5.42
CHEMBL3601718 — IC50 = 3822.0 nM 5.42
CHEMBL3601224 — IC50 = 3871.0 nM 5.41
CHEMBL3601704 — IC50 = 3974.0 nM 5.40
CHEMBL3601728 — IC50 = 4268.0 nM 5.37
CHEMBL3601111 — IC50 = 4553.0 nM 5.34
CHEMBL3601122 — IC50 = 4948.0 nM 5.31
CHEMBL3601709 — IC50 = 5034.0 nM 5.30
CHEMBL3601233 — IC50 = 5195.0 nM 5.28
CHEMBL3601243 — IC50 = 5198.0 nM 5.28
CHEMBL3601121 — IC50 = 5744.0 nM 5.24
CHEMBL3601241 — IC50 = 6792.0 nM 5.17
CHEMBL3601707 — IC50 = 7422.0 nM 5.13