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Assay Detail

CHEMBL3603328

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Functional
Antiproliferative activity against mouse BA/F3 cells expressing TEL-JAK2 after 72 hrs by cell titer glo assay
ChEMBL ↗
65
Total Activities
65
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type BaF3
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Development of Selective Covalent Janus Kinase 3 Inhibitors.
Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS.
J Med Chem (2015) 58 : 6589 -6606
PubMed 26258521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 64 5.26 6.16
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3601228 — — 1 6.16
CHEMBL3601705 — — 1 6.06
CHEMBL3601227 — — 1 6.00
CHEMBL3601226 — — 1 5.99
CHEMBL3601127 — — 1 5.63
CHEMBL3601716 — — 1 5.62
CHEMBL3601229 — — 1 5.57
CHEMBL3601723 — — 1 5.56
CHEMBL3600393 — — 1 5.56
CHEMBL3601108 — — 1 5.56
CHEMBL3601232 — — 1 5.54
CHEMBL3601238 — — 1 5.54
CHEMBL3601715 — — 1 5.52
CHEMBL3601711 — — 1 5.51
CHEMBL3601107 — — 1 5.50
CHEMBL3601223 — — 1 5.50
CHEMBL3601106 — — 1 5.48
CHEMBL3601236 — — 1 5.48
CHEMBL3601231 — — 1 5.43
CHEMBL3601712 — — 1 5.41
CHEMBL3601242 — — 1 5.41
CHEMBL3601244 — — 1 5.40
CHEMBL3601718 — — 1 5.39
CHEMBL3601725 — — 1 5.39
CHEMBL3601713 — — 1 5.37
CHEMBL3601237 — — 1 5.36
CHEMBL3601706 — — 1 5.33
CHEMBL3601704 — — 1 5.30
CHEMBL3601861 — — 1 5.28
CHEMBL3601708 — — 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3601228 — IC50 = 692.0 nM 6.16
CHEMBL3601705 — IC50 = 874.0 nM 6.06
CHEMBL3601227 — IC50 = 993.0 nM 6.00
CHEMBL3601226 — IC50 = 1013.0 nM 5.99
CHEMBL3601127 — IC50 = 2326.0 nM 5.63
CHEMBL3601716 — IC50 = 2426.0 nM 5.62
CHEMBL3601229 — IC50 = 2685.0 nM 5.57
CHEMBL3601723 — IC50 = 2733.0 nM 5.56
CHEMBL3600393 — IC50 = 2776.0 nM 5.56
CHEMBL3601108 — IC50 = 2762.0 nM 5.56
CHEMBL3601232 — IC50 = 2910.0 nM 5.54
CHEMBL3601238 — IC50 = 2916.0 nM 5.54
CHEMBL3601715 — IC50 = 3005.0 nM 5.52
CHEMBL3601711 — IC50 = 3101.0 nM 5.51
CHEMBL3601223 — IC50 = 3194.0 nM 5.50
CHEMBL3601107 — IC50 = 3164.0 nM 5.50
CHEMBL3601106 — IC50 = 3290.0 nM 5.48
CHEMBL3601236 — IC50 = 3290.0 nM 5.48
CHEMBL3601231 — IC50 = 3704.0 nM 5.43
CHEMBL3601712 — IC50 = 3870.0 nM 5.41
CHEMBL3601242 — IC50 = 3878.0 nM 5.41
CHEMBL3601244 — IC50 = 3993.0 nM 5.40
CHEMBL3601718 — IC50 = 4094.0 nM 5.39
CHEMBL3601725 — IC50 = 4047.0 nM 5.39
CHEMBL3601713 — IC50 = 4238.0 nM 5.37
CHEMBL3601237 — IC50 = 4321.0 nM 5.36
CHEMBL3601706 — IC50 = 4733.0 nM 5.33
CHEMBL3601704 — IC50 = 4996.0 nM 5.30
CHEMBL3601861 — IC50 = 5306.0 nM 5.28
CHEMBL3601708 — IC50 = 5575.0 nM 5.25
CHEMBL3601728 — IC50 = 5975.0 nM 5.22
CHEMBL3601230 — IC50 = 5981.0 nM 5.22
CHEMBL3601709 — IC50 = 6039.0 nM 5.22
CHEMBL3601116 — IC50 = 6211.0 nM 5.21
CHEMBL3601224 — IC50 = 6175.0 nM 5.21
CHEMBL3601111 — IC50 = 6223.0 nM 5.21
CHEMBL3601114 — IC50 = 6439.0 nM 5.19
CHEMBL3601726 — IC50 = 6728.0 nM 5.17
CHEMBL3601113 — IC50 = 6960.0 nM 5.16
CHEMBL3601121 — IC50 = 7287.0 nM 5.14
CHEMBL3601120 — IC50 = 7177.0 nM 5.14
CHEMBL3601710 — IC50 = 7731.0 nM 5.11
CHEMBL3601727 — IC50 = 8398.0 nM 5.08
CHEMBL3601243 — IC50 = 8487.0 nM 5.07
CHEMBL3601233 — IC50 = 9087.0 nM 5.04
CHEMBL3601117 — IC50 = 9081.0 nM 5.04
CHEMBL3601119 — IC50 = 9098.0 nM 5.04
CHEMBL3601122 — IC50 = 9354.0 nM 5.03
CHEMBL3601123 — IC50 = 9824.0 nM 5.01
CHEMBL3601241 — IC50 = 9695.0 nM 5.01