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Assay Detail

CHEMBL3603329

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against mouse BA/F3 cells expressing TEL-JAK3 after 72 hrs by cell titer glo assay
ChEMBL ↗
71
Total Activities
71
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type BaF3
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Development of Selective Covalent Janus Kinase 3 Inhibitors.
Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS.
J Med Chem (2015) 58 : 6589 -6606
PubMed 26258521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 69 6.87 8.15
Inhibition 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3601231 — — 1 8.15
CHEMBL3601723 — — 1 8.10
CHEMBL3601242 — — 1 8.00
CHEMBL3601226 — — 1 7.96
CHEMBL3601107 — — 1 7.96
CHEMBL3601233 — — 1 7.96
CHEMBL3601227 — — 1 7.82
CHEMBL3601108 — — 1 7.80
CHEMBL3601705 — — 1 7.77
CHEMBL3601113 — — 1 7.77
CHEMBL3601706 — — 1 7.75
CHEMBL3601115 — — 1 7.72
CHEMBL3601228 — — 1 7.70
CHEMBL3601106 — — 1 7.68
CHEMBL3601116 — — 1 7.66
CHEMBL3601236 — — 1 7.64
CHEMBL3601114 — — 1 7.62
CHEMBL3600393 — — 1 7.55
CHEMBL3601232 — — 1 7.54
CHEMBL3601712 — — 1 7.48
CHEMBL3601120 — — 1 7.47
CHEMBL3601237 — — 1 7.46
CHEMBL3601117 — — 1 7.41
CHEMBL3601118 — — 1 7.35
CHEMBL3601238 — — 1 7.27
CHEMBL3601710 — — 1 7.24
CHEMBL3601111 — — 1 7.17
CHEMBL3601223 — — 1 7.16
CHEMBL3601229 — — 1 7.12
CHEMBL3601121 — — 1 7.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3601231 — IC50 = 7.0 nM 8.15
CHEMBL3601723 — IC50 = 8.0 nM 8.10
CHEMBL3601242 — IC50 = 10.0 nM 8.00
CHEMBL3601226 — IC50 = 11.0 nM 7.96
CHEMBL3601107 — IC50 = 11.0 nM 7.96
CHEMBL3601233 — IC50 = 11.0 nM 7.96
CHEMBL3601227 — IC50 = 15.0 nM 7.82
CHEMBL3601108 — IC50 = 16.0 nM 7.80
CHEMBL3601705 — IC50 = 17.0 nM 7.77
CHEMBL3601113 — IC50 = 17.0 nM 7.77
CHEMBL3601706 — IC50 = 18.0 nM 7.75
CHEMBL3601115 — IC50 = 19.0 nM 7.72
CHEMBL3601228 — IC50 = 20.0 nM 7.70
CHEMBL3601106 — IC50 = 21.0 nM 7.68
CHEMBL3601116 — IC50 = 22.0 nM 7.66
CHEMBL3601236 — IC50 = 23.0 nM 7.64
CHEMBL3601114 — IC50 = 24.0 nM 7.62
CHEMBL3600393 — IC50 = 28.0 nM 7.55
CHEMBL3601232 — IC50 = 29.0 nM 7.54
CHEMBL3601712 — IC50 = 33.0 nM 7.48
CHEMBL3601120 — IC50 = 34.0 nM 7.47
CHEMBL3601237 — IC50 = 35.0 nM 7.46
CHEMBL3601117 — IC50 = 39.0 nM 7.41
CHEMBL3601118 — IC50 = 45.0 nM 7.35
CHEMBL3601238 — IC50 = 54.0 nM 7.27
CHEMBL3601710 — IC50 = 57.0 nM 7.24
CHEMBL3601111 — IC50 = 67.0 nM 7.17
CHEMBL3601223 — IC50 = 69.0 nM 7.16
CHEMBL3601229 — IC50 = 75.0 nM 7.12
CHEMBL3601121 — IC50 = 92.0 nM 7.04
CHEMBL3601235 — IC50 = 99.0 nM 7.00
CHEMBL3601127 — IC50 = 102.0 nM 6.99
CHEMBL3601715 — IC50 = 107.0 nM 6.97
CHEMBL3601243 — IC50 = 109.0 nM 6.96
CHEMBL3601110 — IC50 = 110.0 nM 6.96
CHEMBL3601713 — IC50 = 112.0 nM 6.95
CHEMBL3601244 — IC50 = 114.0 nM 6.94
CHEMBL3601112 — IC50 = 119.0 nM 6.92
CHEMBL3601119 — IC50 = 124.0 nM 6.91
CHEMBL3601230 — IC50 = 125.0 nM 6.90
CHEMBL3601708 — IC50 = 131.0 nM 6.88
CHEMBL3601109 — IC50 = 143.0 nM 6.84
CHEMBL3601727 — IC50 = 144.0 nM 6.84
CHEMBL3601726 — IC50 = 159.0 nM 6.80
CHEMBL3601725 — IC50 = 210.0 nM 6.68
CHEMBL3601716 — IC50 = 307.0 nM 6.51
CHEMBL3601709 — IC50 = 439.0 nM 6.36
CHEMBL3601711 — IC50 = 433.0 nM 6.36
CHEMBL3601707 — IC50 = 465.0 nM 6.33
CHEMBL3601234 — IC50 = 478.0 nM 6.32