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Assay Detail

CHEMBL3603331

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against mouse BA/F3 cells expressing TEL-ABL after 72 hrs by cell titer glo assay
ChEMBL ↗
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type BaF3
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Development of Selective Covalent Janus Kinase 3 Inhibitors.
Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS.
J Med Chem (2015) 58 : 6589 -6606
PubMed 26258521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 64 5.20 6.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3601705 — — 1 6.34
CHEMBL3601227 — — 1 5.81
CHEMBL3601228 — — 1 5.71
CHEMBL3601226 — — 1 5.68
CHEMBL3601706 — — 1 5.67
CHEMBL3601237 — — 1 5.63
CHEMBL3601230 — — 1 5.55
CHEMBL3601711 — — 1 5.54
CHEMBL3601725 — — 1 5.54
CHEMBL3601723 — — 1 5.52
CHEMBL3601708 — — 1 5.52
CHEMBL3601715 — — 1 5.52
CHEMBL3601223 — — 1 5.52
CHEMBL3601106 — — 1 5.50
CHEMBL3601229 — — 1 5.46
CHEMBL3601244 — — 1 5.40
CHEMBL3601704 — — 1 5.40
CHEMBL3601242 — — 1 5.39
CHEMBL3601127 — — 1 5.38
CHEMBL3601107 — — 1 5.36
CHEMBL3601232 — — 1 5.35
CHEMBL3601727 — — 1 5.31
CHEMBL3601728 — — 1 5.29
CHEMBL3601224 — — 1 5.28
CHEMBL3600393 — — 1 5.28
CHEMBL3601113 — — 1 5.27
CHEMBL3601713 — — 1 5.26
CHEMBL3601238 — — 1 5.26
CHEMBL3601119 — — 1 5.22
CHEMBL3601716 — — 1 5.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3601705 — IC50 = 459.0 nM 6.34
CHEMBL3601227 — IC50 = 1558.0 nM 5.81
CHEMBL3601228 — IC50 = 1932.0 nM 5.71
CHEMBL3601226 — IC50 = 2077.0 nM 5.68
CHEMBL3601706 — IC50 = 2140.0 nM 5.67
CHEMBL3601237 — IC50 = 2326.0 nM 5.63
CHEMBL3601230 — IC50 = 2824.0 nM 5.55
CHEMBL3601711 — IC50 = 2848.0 nM 5.54
CHEMBL3601725 — IC50 = 2883.0 nM 5.54
CHEMBL3601723 — IC50 = 2989.0 nM 5.52
CHEMBL3601708 — IC50 = 3021.0 nM 5.52
CHEMBL3601715 — IC50 = 3022.0 nM 5.52
CHEMBL3601223 — IC50 = 3047.0 nM 5.52
CHEMBL3601106 — IC50 = 3136.0 nM 5.50
CHEMBL3601229 — IC50 = 3470.0 nM 5.46
CHEMBL3601244 — IC50 = 3998.0 nM 5.40
CHEMBL3601704 — IC50 = 4020.0 nM 5.40
CHEMBL3601242 — IC50 = 4055.0 nM 5.39
CHEMBL3601127 — IC50 = 4123.0 nM 5.38
CHEMBL3601107 — IC50 = 4374.0 nM 5.36
CHEMBL3601232 — IC50 = 4494.0 nM 5.35
CHEMBL3601727 — IC50 = 4922.0 nM 5.31
CHEMBL3601728 — IC50 = 5098.0 nM 5.29
CHEMBL3601224 — IC50 = 5257.0 nM 5.28
CHEMBL3600393 — IC50 = 5286.0 nM 5.28
CHEMBL3601113 — IC50 = 5398.0 nM 5.27
CHEMBL3601238 — IC50 = 5477.0 nM 5.26
CHEMBL3601713 — IC50 = 5538.0 nM 5.26
CHEMBL3601119 — IC50 = 5973.0 nM 5.22
CHEMBL3601716 — IC50 = 6036.0 nM 5.22
CHEMBL3601718 — IC50 = 6185.0 nM 5.21
CHEMBL3601861 — IC50 = 6671.0 nM 5.18
CHEMBL3601709 — IC50 = 6782.0 nM 5.17
CHEMBL3601114 — IC50 = 6830.0 nM 5.17
CHEMBL3601122 — IC50 = 7594.0 nM 5.12
CHEMBL3601707 — IC50 = 7811.0 nM 5.11
CHEMBL3601121 — IC50 = 8369.0 nM 5.08
CHEMBL3601236 — IC50 = 8769.0 nM 5.06
CHEMBL3601120 — IC50 = 8822.0 nM 5.05
CHEMBL3601714 — IC50 = 8890.0 nM 5.05
CHEMBL3601710 — IC50 = 9942.0 nM 5.00
CHEMBL3601111 — IC50 = 10610.0 nM 4.97
CHEMBL3601243 — IC50 = 11030.0 nM 4.96
CHEMBL3601712 — IC50 = 11040.0 nM 4.96
CHEMBL3601241 — IC50 = 11150.0 nM 4.95
CHEMBL3601116 — IC50 = 11169.0 nM 4.95
CHEMBL3601108 — IC50 = 11820.0 nM 4.93
CHEMBL3601726 — IC50 = 12551.0 nM 4.90
CHEMBL3601117 — IC50 = 13157.0 nM 4.88
CHEMBL3601231 — IC50 = 13705.0 nM 4.86