Assay Detail
Binding
CHEMBL3603349
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Inhibition of PTP1B (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an Indonesian ascidian-derived Penicillium verruculosum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.29 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 6.16 |
| CHEMBL3601068 | — | — | 1 | 5.08 |
| CHEMBL3581315 | — | — | 1 | 5.07 |
| CHEMBL3581318 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3601068 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3581315 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3581318 | — | IC50 | = | 14900.0 | nM | 4.83 |