Assay Detail
Functional
CHEMBL3603434
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Agonist activity at human recombinant beta3-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β3-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.33 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601305 | — | — | 1 | 7.89 |
| CHEMBL3601204 | — | — | 1 | 7.85 |
| CHEMBL3600395 | — | — | 1 | 7.77 |
| CHEMBL3601200 | — | — | 1 | 7.68 |
| CHEMBL3601201 | — | — | 1 | 7.40 |
| CHEMBL3601203 | — | — | 1 | 7.37 |
| CHEMBL3601308 | — | — | 1 | 7.19 |
| CHEMBL3601307 | — | — | 1 | 7.18 |
| CHEMBL3601202 | — | — | 1 | 7.15 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.07 |
| CHEMBL3601310 | — | — | 1 | 6.96 |
| CHEMBL3601306 | — | — | 1 | 6.47 |
| CHEMBL3601309 | — | — | 1 | - |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601305 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3601204 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3600395 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3601200 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3601201 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3601203 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3601308 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3601307 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3601202 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3601310 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL3601306 | — | EC50 | = | 338.0 | nM | 6.47 |
| CHEMBL3601309 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | - | — | - |