Assay Detail
Binding
CHEMBL3603631
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Inhibition of Wnt/beta-catenin (unknown origin)
8
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.16 | 7.39 |
| Kd | 1 | 6.35 | 6.35 |
| Ki | 1 | 4.54 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589010 | — | — | 1 | 7.39 |
| CHEMBL3601405 | — | — | 1 | 6.95 |
| CHEMBL254381 | — | — | 1 | 6.35 |
| CHEMBL228226 | — | — | 1 | 5.96 |
| CHEMBL403296 | — | — | 1 | 4.54 |
| CHEMBL3601404 | — | — | 1 | 4.34 |
| CHEMBL3601411 | TEGAVIVINT | 2.0 | 1 | - |
| CHEMBL1716091 | SDX-101 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589010 | — | IC50 | = | 40.3 | nM | 7.39 |
| CHEMBL3601405 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL254381 | — | Kd | = | 450.0 | nM | 6.35 |
| CHEMBL228226 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL403296 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL3601404 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3601411 | TEGAVIVINT | IC50 | < | 10.0 | nM | - |
| CHEMBL1716091 | SDX-101 | IC50 | = | 687000.0 | nM | - |