Assay Detail
Binding
CHEMBL3606286
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Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.87 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604905 | — | — | 1 | 6.64 |
| CHEMBL2088014 | — | — | 1 | 6.54 |
| CHEMBL3604908 | — | — | 1 | 6.50 |
| CHEMBL3604904 | — | — | 1 | 6.50 |
| CHEMBL3604907 | — | — | 1 | 6.48 |
| CHEMBL3604906 | — | — | 1 | 6.47 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.47 |
| CHEMBL3604909 | — | — | 1 | 6.43 |
| CHEMBL3604895 | — | — | 1 | 6.38 |
| CHEMBL3604893 | — | — | 1 | 6.26 |
| CHEMBL2313077 | — | — | 1 | 6.25 |
| CHEMBL2179173 | — | — | 1 | 6.16 |
| CHEMBL100633 | — | — | 1 | 6.14 |
| CHEMBL3604896 | — | — | 1 | 6.12 |
| CHEMBL589733 | — | — | 1 | 6.05 |
| CHEMBL2088010 | — | — | 1 | 6.00 |
| CHEMBL2313091 | — | — | 1 | 5.92 |
| CHEMBL2088012 | — | — | 1 | 5.89 |
| CHEMBL3604898 | — | — | 1 | 5.85 |
| CHEMBL2088011 | — | — | 1 | 5.78 |
| CHEMBL3604903 | — | — | 1 | 5.59 |
| CHEMBL3604894 | — | — | 1 | 5.52 |
| CHEMBL2312822 | — | — | 1 | 5.42 |
| CHEMBL2313078 | — | — | 1 | 5.40 |
| CHEMBL3604890 | — | — | 1 | 5.19 |
| CHEMBL3604891 | — | — | 1 | 5.12 |
| CHEMBL1892375 | — | — | 1 | 4.93 |
| CHEMBL3604901 | — | — | 1 | 4.82 |
| CHEMBL3604892 | — | — | 1 | 4.82 |
| CHEMBL2312829 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604905 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2088014 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3604904 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3604908 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3604907 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3604906 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3604909 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3604895 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3604893 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2313077 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2179173 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL100633 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3604896 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL589733 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2088010 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2313091 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL2088012 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3604898 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL2088011 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3604903 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL3604894 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL2312822 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL2313078 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL3604890 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL3604891 | — | IC50 | = | 7660.0 | nM | 5.12 |
| CHEMBL1892375 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL3604901 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL3604892 | — | IC50 | = | 15040.0 | nM | 4.82 |
| CHEMBL2312829 | — | IC50 | = | 32890.0 | nM | 4.48 |
| CHEMBL2313086 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL3604899 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL3604900 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL3604902 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL3604897 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL2312828 | — | IC50 | > | 12000.0 | nM | - |