Assay Detail
Functional
CHEMBL3606289
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.21 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.35 |
| CHEMBL3604906 | — | — | 1 | 6.29 |
| CHEMBL2313077 | — | — | 1 | 6.27 |
| CHEMBL3604907 | — | — | 1 | 6.26 |
| CHEMBL3604905 | — | — | 1 | 6.21 |
| CHEMBL2088014 | — | — | 1 | 6.17 |
| CHEMBL3604895 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3604906 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2313077 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3604907 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3604905 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2088014 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3604895 | — | IC50 | = | 1180.0 | nM | 5.93 |