Assay Detail
Binding
CHEMBL3606369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin (unknown origin) assembly pre-incubated for 15 mins before GTP addition measured after 20 mins by turbidimetry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.72 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604200 | — | — | 1 | 6.07 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL3604201 | — | — | 1 | 5.89 |
| CHEMBL3604205 | — | — | 1 | 5.89 |
| CHEMBL3604209 | — | — | 1 | 5.58 |
| CHEMBL3604210 | — | — | 1 | 5.48 |
| CHEMBL3604202 | — | — | 1 | 5.24 |
| CHEMBL3604212 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604200 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3604201 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3604205 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3604209 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3604210 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3604202 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3604212 | — | IC50 | > | 20000.0 | nM | - |