Assay Detail
Binding
CHEMBL3606403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-resolved FRET assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.21 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604943 | — | — | 1 | 8.70 |
| CHEMBL3545308 | ROCILETINIB | 3.0 | 1 | 8.70 |
| CHEMBL1229592 | — | — | 1 | 8.00 |
| CHEMBL3604920 | — | — | 1 | 6.05 |
| CHEMBL3604917 | — | — | 1 | 6.05 |
| CHEMBL3604912 | — | — | 1 | 5.96 |
| CHEMBL3604937 | — | — | 1 | 5.77 |
| CHEMBL3604935 | — | — | 1 | 5.77 |
| CHEMBL3604936 | — | — | 1 | 5.70 |
| CHEMBL3604940 | — | — | 1 | 5.54 |
| CHEMBL3604922 | — | — | 1 | 5.51 |
| CHEMBL3604941 | — | — | 1 | 5.44 |
| CHEMBL3604915 | — | — | 1 | 5.43 |
| CHEMBL3604927 | — | — | 1 | 5.41 |
| CHEMBL3604939 | — | — | 1 | 5.17 |
| CHEMBL3604938 | — | — | 1 | - |
| CHEMBL3604925 | — | — | 1 | - |
| CHEMBL3604916 | — | — | 1 | - |
| CHEMBL3604918 | — | — | 1 | - |
| CHEMBL3604921 | — | — | 1 | - |
| CHEMBL3604914 | — | — | 1 | - |
| CHEMBL3604911 | — | — | 1 | - |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | - |
| CHEMBL3604910 | — | — | 1 | - |
| CHEMBL1232944 | — | — | 1 | - |
| CHEMBL3604924 | — | — | 1 | - |
| CHEMBL3604942 | — | — | 1 | - |
| CHEMBL3604923 | — | — | 1 | - |
| CHEMBL3604913 | — | — | 1 | - |
| CHEMBL3604919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604943 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3545308 | ROCILETINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1229592 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3604920 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3604917 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3604912 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3604937 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3604935 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3604936 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3604940 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3604922 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3604941 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3604915 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3604927 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3604939 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3604926 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604928 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604930 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604931 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604932 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604933 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604934 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604938 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604925 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604916 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604918 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604921 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604914 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604911 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL939 | GEFITINIB | IC50 | < | 1.0 | nM | - |
| CHEMBL3604910 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1232944 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604924 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604942 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604923 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604913 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3604919 | — | IC50 | > | 10000.0 | nM | - |